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Vicente-Gomila, JmAutor o coautor

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The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Publicat a:Pesquisa Brasileira Em Odontopediatria E Clinica Integrada. 22 e210046- - 2022-01-01 22(), DOI: 10.1590/pboci.2022.011

Autors: Martins, ML; Leite, KLD; Magno, MB; Masterson, D; Vicente-Gomila, JM; Cavalcanti, YW; Maia, LC; Fonseca-Gonçalves, A

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Objective: To describe and evaluate the xylitol products' applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans. Material and Methods: Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were: year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects. Results: From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (78.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration >= 15% (p=0.007). Side effects were reported in 8.2% and were associated with posology >= 5 g/day (p=0.05). Conclusion: Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects.

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