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Supported by grants from the Spanish Healthcare Institute Carlos III [PI18/01552] and the Valencian Society of Digestive Pathology [SVPD, Valencia, Spain].

Analysis of institutional authors

Hervas, DavidAuthorForment, JavierAuthorGadea, JoseCorresponding Author

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October 10, 2024
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Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications

Publicated to:Clinical And Translational Gastroenterology. 12 (10): e00416- - 2021-10-01 12(10), DOI: 10.14309/ctg.0000000000000416

Authors: Moret-Tatay, Ines; Cerrillo, Elena; Hervas, David; Iborra, Marisa; Saez-Gonzalez, Esteban; Forment, Javier; Tortosa, Luis; Nos, Pilar; Gadea, Jose; Beltran, Belen

Affiliations

Ctr Invest Biomed Red Enfermedades Hepat & Digest, Hepat & Digest Dis Network, Biomed Res Ctr, Madrid, Spain - Author
Hlth Res IIS La Fe, Biostat Unit, Valencia, Spain - Author
Hosp La Fe, Hlth Res Inst, Inflammatory Bowel Dis Res Grp, IIS La Fe, Valencia, Spain - Author
La Fe Univ & Polytech Hosp, Gastroenterol Dept, Inflammatory Bowel Dis Unit, Valencia, Spain - Author
Univ Politecn Valencia, Inst Plant Mol & Cellular Biol IBMCP, Spanish Res Council CSIC, Valencia, Spain - Author
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Abstract

INTRODUCTION: MicroRNAs (miRNAs) are important epigenetic regulators in Crohn's disease (CD); however, their contribution to postoperative recurrence (POR) is still unknown. We aimed to characterize the potential role of miRNAs in predicting POR in patients with CD and to identify their pathogenic implications. METHODS: Of 67 consecutively operated patients with CD, we included 44 with pure ileal CD. Peripheral blood samples were taken before surgery and during follow-up. The patients were classified according to the presence or absence of POR assessed by ileocolonoscopy or magnetic resonance imaging enterography. The miRNAs were profiled by reverse transcription polymerase chain reaction before surgery and during morphological POR or, for those who remained in remission, 1 year after surgery. R software and mirWalk were used. RESULTS: Five human miRNAs (miR-191-5p, miR-15b-5p, miR-106b-5p, miR-451a, and miR-93-5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). Another 5 (miR-15b-5p, miR-451a, miR-93-5p, miR-423-5p, and miR-125b-5p) were selected for 1 year, with an area under the curve of 0.96 (95% confidence interval [0.91, 1.0]). We also created nomograms for POR risk estimation. CCND2 and BCL9L genes were related to PS miRNA profiles; SENP5 and AKT3 genes were related to PS and 1 year; and SUV39H1 and MAPK3K10 were related to 1 year. DISCUSSION: Different plasma miRNA signatures identify patients at high POR risk, which could help optimize patient outcomes. We developed nomograms to facilitate the clinical use of these results. The identified miRNAs participate in apoptosis, autophagy, proinflammatory immunological T-cell clusters, and reactive oxygen species metabolism.

Keywords

AdultApoptosisBehavioColonoscopyCrohn diseaseExpressionFemaleHumansIdentificationIlealIleumInhibitionMaleMetaanalysisMicrornasMiddle agedNomogramsPostoperative recurrenceRecurrenceResectionRisk assessmentSurgeryYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical And Translational Gastroenterology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Gastroenterology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.94, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 7
  • Scopus: 8
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.95.
  • The number of mentions on the social network X (formerly Twitter): 15 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

the author responsible for correspondence tasks has been Gadea Vacas, José.