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Analysis of institutional authors

Montà-González, GAuthorOrtiz-Gómez, EAuthorLópez-Lima, RAuthorFiorini, GAuthorMartínez-Máñez, RCorresponding AuthorMartí-Centelles, VCorresponding Author

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Review

Water-Soluble Molecular Cages for Biological Applications

Publicated to:Molecules. 29 (7): 1621- - 2024-04-01 29(7), DOI: 10.3390/molecules29071621

Authors: Monta-Gonzalez, Giovanni; Ortiz-Gomez, Eduardo; Lopez-Lima, Rocio; Fiorini, Guillermo; Martinez-Manez, Ramon; Marti-Centelles, Vicente

Affiliations

Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed - Author
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Ave Eduardo Primo Yufera 3 - Author
Univ Politecn Valencia, Dept Quim, Cami Vera S-N - Author
Univ Politecn Valencia, Univ Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Camino Vera S-N - Author

Abstract

The field of molecular cages has attracted increasing interest in relation to the development of biological applications, as evidenced by the remarkable examples published in recent years. Two key factors have contributed to this achievement: First, the remarkable and adjustable host-guest chemical properties of molecular cages make them highly suitable for biological applications. This allows encapsulating therapeutic molecules to improve their properties. Second, significant advances have been made in synthetic methods to create water-soluble molecular cages. Achieving the necessary water solubility is a significant challenge, which in most cases requires specific chemical groups to overcome the inherent hydrophobic nature of the molecular cages which feature the organic components of the cage. This can be achieved by either incorporating water-solubilizing groups with negative/positive charges, polyethylene glycol chains, etc.; or by introducing charges directly into the cage structure itself. These synthetic strategies allow preparing water-soluble molecular cages for diverse biological applications, including cages' anticancer activity, anticancer drug delivery, photodynamic therapy, and molecular recognition of biological molecules. In the review we describe selected examples that show the main concepts to achieve water solubility in molecular cages and some selected recent biological applications.

Keywords

Anticancer applicationsBindingContainer moleculesDrug delivery systemsHost-guest chemistryM2l4 coordination capsulesMetal-organic cagesMolecular cagesOrganic cagesPhotochemotherapyPolyethylene glycolsRecognitionStabilizationSupramolecular chemistrySynthetic lectinsWater

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecules due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmaceutical Science.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-29:

  • WoS: 8
  • Scopus: 8
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 17.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 10.2.
  • The number of mentions on the social network X (formerly Twitter): 15 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Montà González, Giovanni) and Last Author (Martí Centelles, Vicente).

the authors responsible for correspondence tasks have been Martínez Mañez, Ramón and Martí Centelles, Vicente.