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October 11, 2024
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Adenosine A 2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia

Publicated to: BIOMEDICINE & PHARMACOTHERAPY. 173 116401- - 2024-04-01 173(), DOI: 10.1016/j.biopha.2024.116401

Authors:

Marin-Castejon, A; Marco-Bonilla, M; Terencio, MC; Arasa, J; Carceller, MC; Ferrandiz, ML; Noguera, MA; Andres-Ejarque, R; Montesinos, MC
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Affiliations

Fdn Jimenez Diaz UAM, Bone & Joint Res Unit, FIIS - Author
Kings Coll London, Ctr Inflammat Biol & Canc Immunol, Sch Immunol & Microbial Sci - Author
Univ Valencia, Dept Pharmacol, Av Vicent Andres Estelles S-N - Author
Univ Valencia, Fac Pharm & Food Sci, Dept Pharm Pharmaceut Technol & Parasitol, Av Vicent Andres Estelles S-N, Burjassot 46100 - Author
Univ Valencia, Inst Univ Biotecnol & Biomed BIOTECMED, Av Vicent A Estelles S-N, Burjassot 46100 - Author
Univ Valencia, Interuniv Res Inst Mol Recognit & Technol Dev IDM, Polytech Univ Valencia, Av Vicent A Estelles S-N, Burjassot 46100 - Author
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Abstract

Adenosine regulates multiple physiological processes through the activation of four receptor subtypes, of which the A 2B adenosine receptor (A 2B AR) has the lowest affinity for adenosine. Being the adenosine receptor subtype most prominently expressed in epidermis, we recently described the antiproliferative and anti-inflammatory effect of the selective A 2B AR agonist BAY60 -6583 (BAY) in human keratinocytes stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA), so we sought to establish the effect of topical application of BAY in a model of murine epidermal hyperplasia. Topical application of BAY (1 or 10 mu g/site) prevented the inflammatory reaction and skin lesions induced by TPA, minimizing hyperproliferation and acanthosis, as well as the expression of specific markers of proliferative keratinocytes. On the other hand, pre-treatment with the selective A 2B AR antagonist, PSB-1115 (PSB, 5 or 50 mu g/ site) reversed these beneficial effects. Additionally, BAY application normalized the expression of epidermal barrier proteins, whose integrity is altered in inflammatory skin diseases, while treatment with the antagonist alone worsened it. Our results, besides confirming the anti-inflammatory and antiproliferative effects of the A2BAR agonist, further demonstrate a role of A 2B AR activation to preserve the epidermal barrier. Therefore, the activation of A 2B AR may constitute a possible new pharmacological target for the treatment of skin inflammatory diseases such as psoriasis.
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Keywords

A(2a) receptorA(2b) receptorsAdenosine a2b receptorAngiogenesisCaspase-14Epidermal barrierExpressionFilaggrinInhibitionInvolucrinKeratinocyte proliferationNf-kappa-bPsoriasisSkin barrierSuppressor-cells

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BIOMEDICINE & PHARMACOTHERAPY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 19/352, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-03:

  • WoS: 7
  • Scopus: 8
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Marin-Castejon, A) .

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