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Analysis of institutional authors

Saiz, JCorresponding AuthorMonserrat, MAuthorFerrero, JmAuthorGomis-Tena, JAuthorAlonso, JAuthor

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October 11, 2024
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Modulation of the regional dispersion of repolarization by the action of class III antiarrhythmic drug dofetilide

Publicated to:Computers In Cardiology. 32 885-888 - 2005-01-01 32(), DOI: 10.1109/CIC.2005.1588248

Authors: Saiz, J; Monserrat, M; Ferrero, JM; Gomis-Tena, J; Cardona, K; Chorro, J; Alonso, J

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Abstract

It is well known that short-long (S-L) sequences frequently precede the onset of malignant ventricular arrhythmias. Experimental studies have shown that a single long coupled extra-beat (L) after a previous basic cycle length resulted in a critical increase of the dispersion of repolarization pattern that promoted re-entrant excitation. However, in normal intact heart little differences in repolarization among different myocardial layers have been observed after abrupt slowing of heart rate. We used the Luo and Rudy model (LRd00) of AP and the model of IKr blockade by the action of dofetilide previously developed by our group to study the effect of dofetilide (a class III antiarrhythmic drug) on the modulation of APD dispersion in a strand of ventricular tissue. Our results show that dofetilide increases dramatically the APD of the strand and that the effect of dofetilide on the modulation of dispersion is complex, indicating that the highest dispersion could appear before the highest effect of the drug is reached.

Keywords

Action-potential durationAgentArrhythmogenicityBlockHearHeterogeneityK+-currentLong-qt syndrome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-16:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Saiz Rodríguez, Francisco Javier) and Last Author (Alonso Abalos, José Miguel).

the author responsible for correspondence tasks has been Saiz Rodríguez, Francisco Javier.