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Analysis of institutional authors

Alfonso, MaríaAuthorMorella-Aucejo, ángelaAuthorSancenon, FelixAuthorMartinez-Manez, RamonCorresponding Author

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October 12, 2024
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Senolysis Reduces Senescence in Veins and Cancer Cell Migration

Publicated to: Advanced Therapeutics. 4 (2100149): 2100149- - 2021-01-01 4(2100149), DOI: 10.1002/adtp.202100149

Authors:

Estepa-Fernández, Alejandra; Alfonso-Navarro, María; Morella-Aucejo, Ángela; García-Fernández, Alba; Lerida-Viso, Araceli; Lozano-Torres, Beatriz; Galiana, Irene ; Soriano-Teruel, P.M.; Sancenón Galarza, Félix; Orzaez, M.; Martínez-Máñez, Ramón
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Affiliations

CIBER Bioingn, Biomat Nanomed CIBER BBN, Av Monforte Lemos,3-5 Pabellon 11 Planta 0, Madrid 28029, Spain - Author
Ctr Invest Principe Felipe, C Eduardo Primo Yufera 3, Valencia 46012, Spain - Author
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermed, C Eduardo Primo Yufera 3, Valencia 46012, Spain - Author
Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarr, Camino Vera S-N, Valencia 46022, Spain - Author
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, IIS Fe Av Fernando Abril Martorell,106 Torre 7 Pl, Valencia 46026, Spain - Author
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Abstract

Senescence is a persistent state of cell cycle arrest. Induction of senescence has been explored as a barrier against tumor progression and is used as a therapeutic option. Despite the advantages of the introduction of senescence-inducing compounds in the clinic, recent studies show that their side-effects can be partially masking their antitumor potential. This is due to the deleterious effects that accumulation of senescent cells in tissues and organs causes on tissue microenvironment that confer tumor-promoting properties. In this study, it is demonstrated that the presence of senescent endothelium favors cancer cell migration and show that palbociclib systemic treatment induces senescence in veins in an orthotopic triple-negative breast cancer mouse model. Moreover, it is found that following palbociclib-induced senogenesis, the elimination of senescent cells using the nanoencapsulated senolytic navitoclax (NP(nav)-Gal) produces the selective elimination of endothelial senescent cells and induces a marked recovery of endothelial tissue functionality. Finally, the treatment with NP(nav)-Gal produces a significant decrease of senescence in veins which is consistent with the decrease in metastasic burden observed. These results evidence the potential of reducing vascular senescence using senolytic therapies as a strategy to limit the metastatic dissemination of tumors cells in breast cancer patients subjected to chemotherapeutic treatments.
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Keywords

ChemotherapyDependent kinase 4/6Endothelial cellsEndothelial cells,mesoporous nanoparticles,navitoclax,palbociclib,senescence,triple negative breast cancerEndothelial-cellsFda approvalMesoporous nanoparticlesMesoporous silica materialsMetastasisNanoparticlesNavitoclaxPalbociclibSecretory phenotypeSenescenceSurveillancTriple negative breast cance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Advanced Therapeutics due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmaceutical Science. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.34. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.31 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-11, the following number of citations:

  • WoS: 18
  • Scopus: 17
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-11:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Estepa-Fernández, Alejandra) and Last Author (Martínez Mañez, Ramón).

the authors responsible for correspondence tasks have been Garcia-Fernandez, Alba, Orzaez, Mar and Martínez Mañez, Ramón.

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Awards linked to the item

R.M.-M. and laboratory members thank the financial support from the Spanish Government (projects RTI2018-100910-B-C41 and RTI2018-101599-B-C22 (MCUI/FEDER, EU)) and the Generalitat Valenciana (project PROMETEO 2018/024). A.E-F. and B. L-T. are grateful to the Spanish Ministry of Economy for their Ph.D. grants (FPU17/05454 and FPU15/02707). A.L.-V. thanks Instituto de Salud Carlos III for the grant through the project "IFI17/00039" co-funded by European Social Fund "Investing in your future". M.O. thanks the financial support from SAF2017-84689-R project and MINECO/AEI/FEDER, UE. M.A. thanks her postdoctoral fellowship (PAID-10-17). The funders had no role in the design, data collection, decision to publish, or preparation of the manuscript. The authors thank Alberto Hernandez for confocal microscope assistance and Alicia Martinez for the flow cytometry assistance.
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