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Analysis of institutional authors

Sala-Mira, IvánAuthorGarcia, PedroAuthorGarcía Gil, Pedro JoséAuthorDiez, José-LuísAuthorBondía, JorgeCorresponding Author

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October 13, 2024
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Article

Internal model control based module for the elimination of meal and exercise announcements in hybrid artificial pancreas systems

Publicated to: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 226 1-13 - 2022-01-01 226(), DOI: 10.1016/j.cmpb.2022.107061

Authors:

Sala-Mira, Iván; García Gil, Pedro José; Diez, José-Luís; Bondia, Jorge
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Affiliations

Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain - Author
Univ Politecn Valencia, Inst Univ Automat & Informat Ind, Valencia 46022, Spain - Author

Abstract

Background and Objectives: Hybrid artificial pancreas systems outperform current insulin pump therapies in blood glucose regulation in type 1 diabetes. However, subjects still have to inform the system about meals intake and exercise to achieve reasonable control. These patient announcements may result in overburden and compromise controller performance if not provided timely and accurately. Here, a hybrid artificial pancreas is extended with an add-on module that releases subjects from meals and exercise announcements. Methods: The add-on module consists of an internal-model controller that generates a "virtual" control action to compensate for disturbances. This "virtual" action is converted into insulin delivery, rescue carbohydrates suggestions, or insulin-on-board limitations, depending on a switching logic based on glucose measurements and predictions. The controller parameters are tuned by optimization and then related to standard parameters from the open-loop therapy. This module is implemented in a hybrid artificial pancreas system proposed by our research group for validation. This hybrid system extended with the add-on module is compared with the hybrid controller with carbohydrate counting errors (hybrid) and the hybrid controller with an alternative unannounced meal compensation module based on a meal detection algorithm (meal detector). The validation used the educational version of the UVa/Padova simulator to simulate the three controllers under two scenarios: one with only meals and another with meals and exercise. The exercise was modeled as a temporal increase of the insulin sensitivity resulting in the glucose drop usually related to an aerobic exercise. Results: For the scenario with only meals, the three controllers achieved similar time in range (proposed: 85.1 [77.9,88.1]%, hybrid: 84.0 [75.9,86.4]%, meal detector: 81.9 [79.3,83.8]%, median [interquartile range]) with low time in moderate hypoglycemia. Under the scenario with meals and exercise, the proposed module reduces 4.61% the time in hypoglycemia achieved with the other controllers, suggesting an acceptable amount of rescues (27.2 [23.7, 31.0] g). Conclusions: The proposed add-on module achieved promising results: it outperformed the mealdetector-based controller, even achieving a postprandial performance as good as the hybrid controller (with carbohydrate counting errors). Also, the rescue suggestion feature of the module mitigated exercise-induced hypoglycemia with admissible rescue amounts. (C) 2022 Elsevier B.V. All rights reserved.
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Keywords

AdolescentsAlgorithmsArtificial pancreasBlood glucoseBlood glucose self-monitoringClosed-loop controlDiabetes mellitus, type 1Disturbance rejectioDisturbance rejectionExerciseFeedbackGlucoseGlucose controlHumansHypoglycemiaHypoglycemia avoidanceHypoglycemic agentsInsulinInsulin infusion systemsInternal model controlLimitationMealsPancreas, artificialPostprandial controlSafetType 1 diabetes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 15/111, thus managing to position itself as a Q1 (Primer Cuartil), in the category Computer Science, Theory & Methods.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 7
  • Scopus: 9
  • Europe PMC: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SALA MIRA, IVÁN) and Last Author (Bondía Company, Jorge).

the author responsible for correspondence tasks has been Bondía Company, Jorge.

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Awards linked to the item

This work was partially supported by: grant PID2019-107722RBC21 funded by MCIN/AEI/10.13039/50110 0 011033 and grant ACIF/2017/021 funded by the Generalitat Valenciana through FSE funds.
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