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Lopez, AlejandroAuthorFerrer, AnaAuthorMartinez, LauraAuthorSaiz, JavierCorresponding AuthorA Highly-Detailed 3D Model of the Human Atria
Publicated to:World Congress On Medical Physics And Biomedical Engineering: Radiation Oncology. 68 (1): 649-653 - 2019-01-01 68(1), DOI: 10.1007/978-981-10-9035-6_121
Authors: Rocher, Sara; Lopez, Alejandro; Ferrer, Ana; Martinez, Laura; Sanchez, Damian; Saiz, Javier
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Abstract
The underlaying mechanisms of atrial fibrillation and the involved factors in the chronicity of the disease are object of great interest nowadays. Multiscale cardiac modelling has become a powerful tool since it can help to better understand the physiopathology of arrhythmias. In this study we present a "true" 3D model of the human atria with anatomical and functional heterogeneity. The model includes a realistic definition of the atrial wall thickness and transmurality in fibres orientation. The electrical behaviour of the new model was validated by comparing the propagation sequence in sinus rhythm with respect to experimental activation times. The model was used for arrhythmogenic studies by adding electrical remodelling. We compared the fibrillatory activity of the new model with two models less detailed anatomically but with the same electrophysiological properties. The three models reproduced different fibrillatory patterns with the appearance of rotors in different areas, demonstrating that the anatomical properties of the model affect the electrical behaviour of the simulation. Our results suggest that it is very important to implement highly-detailed models to obtain results as close as possible to the real system.
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Bibliometric impact. Analysis of the contribution and dissemination channel
Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.
Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-26:
- WoS: 2
- Scopus: 2
Impact and social visibility
Leadership analysis of institutional authors
There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rocher, Sara) and Last Author (Saiz Rodríguez, Francisco Javier).
the author responsible for correspondence tasks has been Saiz Rodríguez, Francisco Javier.