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Analysis of institutional authors

Burgos-Simon, ClaraAuthorMartínez-Rodríguez, DavidAuthorVillanueva, Rafael-JacintoCorresponding Author

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October 15, 2024
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Mathematical modeling of the dynamics of the bladder cancer and the immune response applied to a patient: Evolution and short-term prediction

Publicated to: MATHEMATICAL METHODS IN THE APPLIED SCIENCES. 42 (17): 5746-5757 - 2019-01-01 42(17), DOI: 10.1002/mma.5536

Authors:

Burgos-Simon, Clara; García-Medina, N.; Martínez-Rodríguez, David; Villanueva Micó, Rafael Jacinto
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Affiliations

Univ Politecn Valencia, Inst Univ Matemat Multidisciplinar, Valencia, Spain - Author

Abstract

Bladder cancer is one of the most common malignant diseases in the urinary system and a highly aggressive neoplasm. The prognosis is not favorable usually, and its evolution for particular patients is very difficult to find out. In this paper, we propose a dynamic mathematical model that describes the bladder tumor growth and the immune response evolution. This model is customized for a single patient, determining appropriate model parameter values via model calibration. Due to the uncertainty of the tumor evolution, using the calibrated model parameters, we predict the tumor size and the immune response evolution over the next few months assuming three different scenarios: favorable, neutral, and unfavorable. In the former, it is not expected any trace of the cancer in the middle of September 2018 (after 16 mo). In the neutral scenario, at the same date, a 7- to 8-mm tumor is expected. In the worst case, a 40-mm tumor is expected. The patient was cited on 10 September 2018 to check the tumor size, and according to the doctors, there was no sign of recurrence. It seems that we are in the favorable scenario. The patient will be called again for follow-up in mid-2019.
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Keywords

Bladder cancerCancer prognosisDynamic modelMechanisModel calibrationPrognosisUncertainty quantificatioUncertainty quantification

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MATHEMATICAL METHODS IN THE APPLIED SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Engineering (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 5
  • Scopus: 5
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/10251/157499
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (BURGOS SIMON, CLARA) and Last Author (Villanueva Micó, Rafael Jacinto).

the author responsible for correspondence tasks has been Villanueva Micó, Rafael Jacinto.

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Awards linked to the item

This work has been supported by the Ministerio de Economía, Industria y Competitividad grant MTM2017-89664-P.
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