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Analysis of institutional authors

Sanz-Navarro, SAuthor

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October 28, 2024
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Degradation of Penicillinic Antibiotics and β-Lactamase Enzymatic Catalysis in a Biomimetic Zn-Based Metal-Organic Framework

Publicated to:Chemistry-A European Journal. 29 (59): e202301325- - 2023-10-23 29(59), DOI: 10.1002/chem.202301325

Authors: Escamilla, P; Bartella, L; Sanz-Navarro, S; Percoco, RM; Di Donna, L; Prejanò, M; Marino, T; Ferrando-Soria, J; Armentano, D; Leyva-Pérez, A; Pardo, E

Affiliations

Univ Calabria, AGRINFRA Res Net, QUASIORA Lab, I-87036 Arcavacata Di Rende - Author
Univ Calabria, Dipartimento Chim & Tecnol Chim, I-87030 Arcavacata Di Rende - Author
Univ Politecn Valencia Consejo Super Invest Cient, Inst Tecnol Quim - Author
Univ Valencia, Inst Ciencia Mol ICMol, Paterna 46980 - Author

Abstract

beta-Lactam antibiotics are one of the most commonly prescribed drugs to treat bacterial infections. However, their use has been somehow limited given the emergence of bacteria with resistance mechanisms, such as beta-lactamases, which inactivate them by degrading their four-membered beta-lactam rings. So, a total knowledge of the mechanisms governing the catalytic activity of beta-lactamases is required. Here, we report a novel Zn-based metal-organic framework (MOF, 1), possessing functional channels capable to accommodate and interact with antibiotics, which catalyze the selective hydrolysis of the penicillinic antibiotics amoxicillin and ceftriaxone. In particular, MOF 1 degrades, very efficiently, the four-membered beta-lactam ring of amoxicillin, acting as a beta-lactamase mimic, and expands the very limited number of MOFs capable to mimic catalytic enzymatic processes. Combined single-crystal X-ray diffraction (SCXRD) studies and density functional (DFT) calculations offer unique snapshots on the host-guest interactions established between amoxicillin and the functional channels of 1. This allows to propose a degradation mechanism based on the activation of a water molecule, promoted by a Zn-bridging hydroxyl group, concertedly to the nucleophilic attack to the carbonyl moiety and the cleaving of C-N bond of the lactam ring.

Keywords

AcidActive-siteAmoxicillinAnti-bacterial agentsAntibioticsAntiinfective agentBacterial infectionsBeta lactamBeta lactamaseBeta-lactamaseBeta-lactamasesBeta-lactamsBiodegradationBiomimeticsBiomimicryCatalyseCatalysisCatalyst activityChemistryComplexesCrystal-structureDegradationEnzymatic catalysisEnzymesEvolutionFunctional channelsLigandMetal organic frameworkMetal-organic frameworkMetal-organic frameworksMetalorganic frameworks (mofs)Metal–organic frameworkMoleculesPenicillin derivativePenicillinsProductsResistanceResistance mechanismsSingle crystalsZincΒ-lactam antibioticsΒ-lactamase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Chemistry-A European Journal due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Organic Chemistry.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.65, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-05, the following number of citations:

  • WoS: 4
  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 15.85.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

the author responsible for correspondence tasks has been Leyva-Pérez, A.