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October 29, 2024
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Article
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Photoinduced N-demethylation of rufloxacin and its methyl ester under aerobic conditions

Publicated to: PHOTOCHEMISTRY AND PHOTOBIOLOGY. 76 (3): 252-258 - 2002-09-01 76(3), DOI: 10.1562/0031-8655(2002)076<0252:PNDORA>2.0.CO;2

Authors:

Belvedere, A; Boscá, F; Cuquerella, MC; de Guidi, G; Miranda, MA
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Affiliations

- Author

Abstract

Irradiation of rufloxacin (RF) under aerobic conditions gives rise to N-demethylation of the piperazinyl ring, which is enhanced in aerated D2O. Two primary processes seem to be involved in P.F N-demethylation: photoionization from IRF and singlet oxygen generation from (PF)-P-3. Both processes may lead to the same key intermediates, namely, RF.+ and superoxide radical anion; coupling of these intermediates explains N-demethylation of RF via an iminium cation. Formation of the hydrated electron by a monophotonic process (with a quantum yield of 0.09) is detected along with (RF)-R-3 (with a intersystem-crossing quantum yield phi(ISC) = 0.36) by laser flash photolysis. Studies performed on RF methyl ester give qualitatively similar results.
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Keywords

Anti-infective agentsAntibacterialsAntibiotic agentAntiinfective agentArticleChemistryCleavageDemethylationDrug degradationFluoroquinolonesHigh performance liquid chromatographyIrradiationLomefloxacinMechanismMethylationNorfloxacinPhotochemistryPhotodegradation productsPhotolysisPhotophysical propertiesPhotosensitizationQuinoline derived antiinfective agentQuinolone derivativeQuinolonesRufloxacinRufloxacin methyl esterSinglet oxygenSpectrofluorometrySpectrometry, fluorescenceUltraviolet spectrophotometryUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PHOTOCHEMISTRY AND PHOTOBIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2002, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 21
  • Scopus: 25
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Miranda, MA).

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