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October 30, 2024
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Review
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New potential therapeutic approaches targeting synovial fibroblasts in rheumatoid arthritis

Publicated to: BIOCHEMICAL PHARMACOLOGY. 194 114815- - 2021-12-01 194(), DOI: 10.1016/j.bcp.2021.114815

Authors:

Alcaraz, MJ
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Affiliations

Univ Valencia, Interuniv Res Inst Mol Recognit & Technol Dev IDM, Polytech Univ Valencia, Av Vicent A Estelles S-N - Author

Abstract

Synovial cells play a key role in joint destruction during chronic inflammation. In particular, activated synovial fibroblasts (SFs) undergo intrinsic alterations leading to an aggressive phenotype mediating cartilage destruction and bone erosion in rheumatoid arthritis (RA). Recent research has revealed a number of targets to control arthritogenic changes in SFs. Therefore, identification of SF phenotypes, control of epigenetic changes, modulation of cellular functions, or regulation of the activity of cation channels and different signaling pathways has been investigated. Although many of these approaches have shown efficacy in vitro and in animal models of RA, further research is needed to select the most relevant targets for drug development. This review is focused on the role of SFs as a potential strategy to discover novel therapeutic targets in RA aimed at preserving joint architecture and function.
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Keywords

ActivationAnimalAnimalsAntirheumatic agentAntirheumatic agentsApoptosisArthritis, rheumatoidAutacoidCadherin-11Cation transportCell agingCell cycleCell deathCell interactionCell metabolismDrug delivery systemDrug delivery systemsDrug effectDrug targetEpigeneticsExpressionExtracellular matrixFibroblastFibroblastsHumanHumansImmunosuppressive agentImmunosuppressive agentsIn vitro studyInflammationInflammation mediatorsInhibitionJoint destructionKca1.1 channelsKinaseMetabolismNonhumanPathologyPhenotypePhysiologyProceduresProliferationReviewRheumatoid arthritisSignal transductionSynovial fibroblastSynoviocyteSynoviocytes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BIOCHEMICAL PHARMACOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 46/279, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.63. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.44 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-02, the following number of citations:

  • WoS: 22
  • Scopus: 26
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 35 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Alcaraz, MJ) and Last Author (Alcaraz, MJ).

the author responsible for correspondence tasks has been Alcaraz, MJ.

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