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Analysis of institutional authors

Megías, RAuthorVercher-Martínez, ACorresponding AuthorBelda, RAuthorGiner, EAuthor

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October 30, 2024
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Numerical modelling of cancellous bone damage using an orthotropic failure criterion and tissue elastic properties as a function of the mineral content and microporosity

Publicated to:Computer Methods And Programs In Biomedicine. 219 106764- - 2022-06-01 219(), DOI: 10.1016/j.cmpb.2022.106764

Authors: Megias, Raquel; Vercher-Martinez, Ana; Belda, Ricardo; Luis Peris, Jose; Larrainzar-Garijo, Ricardo; Giner, Eugenio; Javier Fuenmayor, F

Affiliations

Univ Complutense Madrid, Hosp Univ Infanta Leonor, Med Sch, Orthoped & Trauma Dept - Author
Univ Politecn Valencia, Dept Ingn Mecan & Mat, Inst Ingn Mecan & Biomecan Valencia I2MB, Bldg 5E-9C - Author
Univ Politecn Valencia, Inst Ingn Mecan & Biomecan Valencia I2MB, Healthcare Technol Grp GTS IBV, Bldg 5E-9C - Author

Abstract

Background and objective: Elastic and strength properties of lamellar tissue are essential to analyze the mechanical behaviour of bone at the meso- or macro-scale. Although many efforts have been made to model the architecture of cancellous bone, in general, isotropic elastic constants are assumed for tissue modelling, neglecting its non-isotropic behaviour. Therefore, isotropic damage laws are often used to estimate the bone failure. The main goals of this work are: (1) to present a new model for the estimation of the elastic properties of lamellar tissue which includes the bone mineral density (BMD) and the microporosity, (2) to address the numerical modelling of cancellous bone damage using an orthotropic failure criterion and a discrete damage mechanics analysis, including the novel approach for the tissue elastic properties aforementioned. Methods: Numerical homogenization has been used to estimate the elastic properties of lamellar bone considering BMD and microporosity. Microcomputed Tomography (mu-CT) scans have been performed to obtain the micro-finite element (mu-FE) model of cancellous bone from a vertebra of swine. In this model, lamellar tissue is orientated by considering a unidirectional layer pattern being the mineralized collagen fibrils aligned with the most representative geometrical feature of the trabeculae network. We have considered the Hashin's failure criterion and the Material Property Degradation (MPDG) method for simulating the onset and evolution of bone damage. Results: The terms of the stiffness matrix for lamellar tissue are derived as functions of the BMD and microporosity at tissue scale. Results obtained for the apparent yield strain values agree with experimental values found in the literature. The influence of the damage parameters on the bone mechanics behaviour is also presented. Conclusions: Stiffness matrix of lamellar tissue depends on both BMD and microporosity. The new approach presented in this work enables to analyze the influence of the BMD and porosity on the mechanical response of bone. Lamellar tissue orientation has to be considered in the mechanical analysis of the cancellous bone. An orthotropic failure criterion can be used to analyze the bone failure onset instead of isotropic criteria. The elastic property degradation method is an efficient procedure to analyze the failure propagation in a 3D numerical model. (C) 2022 Elsevier B.V. All rights reserved.

Keywords

AccumulationAnimalAnimal experimentAnimal modelAnimal tissueAnimalsArticleBehaviorBiological modelBoneBone and bonesBone damagesBone densityBone injuryBone mineral densityCancellous boneCancellous bone numerical modelingCancellous bone numerical modellingCollagen fibrilComputerized tomographyControlled studyDamage initiationDiagnostic imagingDisease simulationElastic propertiesElastic tissueElasticityFailure (mechanical)Failure criteriaFinite element analysisFinite element methodFinite-element modelHeterogeneityHomogenization methodLamellar boneLamellar bone porosityLumbar vertebraMaterial properties degradationsMaterial property degradationMechanical stressMicro-computed tomographyMicroporosityMineralMineralsModels, biologicalNonhumanNumerical methodsNumerical modelsOrthotropic failure criteriaOrthotropic failure criterionPigPorosityRigidityStiffnessStiffness matrixStress strain relationshipStress, mechanicalSwineTrabecular boneWorkflowX-ray microtomography

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Computer Methods And Programs In Biomedicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 15/111, thus managing to position itself as a Q1 (Primer Cuartil), in the category Computer Science, Theory & Methods.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.81, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-19, the following number of citations:

  • WoS: 7
  • Scopus: 6
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Megías Díaz, Raquel) and Last Author (Fuenmayor, FJ).

the author responsible for correspondence tasks has been Vercher Martínez, Ana.