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Analysis of institutional authors

Aguilera-Morillo, McAuthor

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October 30, 2024
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Clinical assessment of W-band spectroscopy for non-invasive detection and monitoring of sustained hyperglycemia

Publicated to: Biomedical Optics Express. 12 (8): 5008-5022 - 2021-01-01 12(8), DOI: 10.1364/BOE.428524

Authors:

Moreno-Oyervides, A.; Aguilera-Morillo, M. Carmen; María José de la Cruz-Fernández; Edurne Lecumberri-Pascual; Lucía Llanos-Jiménez; Krozer, Viktor ; Acedo, Pablo
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Affiliations

Fdn Jiminez Diaz IIS FJD, Inst Invest Sanitaria - Author
Goethe Univ Frankfurt Am Main, Phys Inst - Author
Hosp Univ Ramon y Cajal, Serv Endocrinol & Nutr - Author
Univ Politecn Valencia, Dept Appl Stat & Operat Res & Qual - Author
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Abstract

HbA1c is the gold standard test for monitoring medium/long termglycemia conditions in diabetes care, which is a critical factor in reducing the risk of chronic diabetes complications. Current technologies for measuring HbA1c concentration are invasive and adequate assays are still limited to laboratory-based methods that are not widely available worldwide. The development of a non-invasive diagnostic tool for HbA1c concentration can lead to the decrease of the rate of undiagnosed cases and facilitate early detection in diabetes care. We present a preliminary validation diagnostic study of W-band spectroscopy for detection and monitoring of sustained hyperglycemia, using the HbA1c concentration as reference. A group of 20 patients with type 1 diabetes mellitus and 10 healthy subjects were non-invasively assessed at three different visits over a period of 7 months by a millimeter-wave spectrometer (transmission mode) operating across the full W-band. The relationship between the W-band spectral profile and the HbA1c concentration is studied using longitudinal and non-longitudinal functional data analysis methods. A potential blind discrimination between patients with or without diabetes is obtained, and more importantly, an excellent relation (R-squared = 0.97) between the non-invasive assessment and the HbA1c measure is achieved. Such results support that W-band spectroscopy has great potential for developing a non-invasive diagnostic tool for in-vivo HbA1c concentration monitoring in humans. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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Keywords

AdultAgedArticleBlood glucose monitoringBlood pressureBody massChemical detectionCholesterolClinical articleClinical assessmentClinical assessmentsComplicationsConcentration monitoringCreatinineDiabetes-mellitusDiagnosisDiagnostic procedureDiagnostic productsDiagnostic valueFemaleFunctional data analysisGlucoseGlycation end-productsHba1cHemoglobinHemoglobin a1cHigh performance liquid chromatographyHumanHyperglycemiaInsulin dependent diabetes mellitusLiver enzymeMaleMetabolic regulationMillimeter wavesMillimeter-wave spectrometersNon-invasive assessmentsNon-invasive detectionNon-invasive diagnosticsNoninvasive medical proceduresPilot studyProspective studyRaman-spectroscopySpectrometersSpectroscopyTriacylglycerolType 1 diabetes mellitusValidation process

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Biomedical Optics Express due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Atomic and Molecular Physics, and Optics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-03:

  • WoS: 2
  • Scopus: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

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Awards linked to the item

Instituto de Salud Carlos III (DTS17/00135); Comunidad de Madrid (EPUC3M26).
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