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Analysis of institutional authors

Rodenas-Rochina, JAuthor

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October 30, 2024
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Elastin-Plasma Hybrid Hydrogels for Skin Tissue Engineering

Publicated to:Polymers. 13 (13): 2114- - 2021-07-01 13(13), DOI: 10.3390/polym13132114

Authors: Stojic, Marija; Rodenas-Rochina, Joaquin; Luisa Lopez-Donaire, Maria; Gonzalez de Torre, Israel; Gonzalez Perez, Miguel; Carlos Rodriguez-Cabello, Jose; Vojtova, Lucy; Jorcano, Jose Luis; Velasco, Diego

Affiliations

Brno Univ Technol, CEITEC Cent European Inst Technol, Purkynova 123 - Author
Inst Invest Sanitaria Gregorio Maranon - Author
Univ Carlos III Madrid UC3M, Dept Bioengn & Aerosp Engn, Ave Univ 30 - Author
Univ Politecn Valencia, CBIT, Ctr Biomat & Tissue Engn, Camino Vera S-N - Author
Univ Valladolid, CIBER BBN, BIOFORGE Grp Adv Mat & Nanobiotechnol - Author
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Abstract

Dermo-epidermal equivalents based on plasma-derived fibrin hydrogels have been extensively studied for skin engineering. However, they showed rapid degradation and contraction over time and low mechanical properties which limit their reproducibility and lifespan. In order to achieve better mechanical properties, elasticity and biological properties, we incorporated a elastin-like recombinamer (ELR) network, based on two types of ELR, one modified with azide (SKS-N-3) and other with cyclooctyne (SKS-Cyclo) chemical groups at molar ratio 1:1 at three different SKS (serine-lysine-serine sequence) concentrations (1, 3, and 5 wt.%), into plasma-derived fibrin hydrogels. Our results showed a decrease in gelation time and contraction, both in the absence and presence of the encapsulated human primary fibroblasts (hFBs), higher mechanical properties and increase in elasticity when SKSs content is equal or higher than 3%. However, hFBs proliferation showed an improvement when the lowest SKS content (1 wt.%) was used but started decreasing when increasing SKS concentration at day 14 with respect to the plasma control. Proliferation of human primary keratinocytes (hKCs) seeded on top of the hybrid-plasma hydrogels containing 1 and 3% of SKS showed no differences to plasma control and an increase in hKCs proliferation was observed for hybrid-plasma hydrogels containing 5 wt.% of SKS. These promising results showed the need to achieve a balance between the reduced contraction, the better mechanical properties and biological properties and indicate the potential of using this type of hydrogel as a testing platform for pharmaceutical products and cosmetics, and future work will elucidate their potential.

Keywords

Amino acidsBilayered in vitro skin substitutesBiocompatibilityBioengineered skinBiological propertiesCell cultureCollagen latticesElasticityElastinElastin like recombinamersExtracellular-matrixFibrin hydrogelsFibrin polymerizationFibroblastsGelationGlycoproteinsGrowthHuman plasma-derived fibrin hydrogelsHybrid hydrogelsHybrid plasma-elastin hydrogelsHydrogelsIn-vitro evaluationModelMolar concentrationMolar ratioPharmaceutical productsPlasma confinementPlatelet-rich plasmaProtein-based polymersRapid degradationReproducibilitiesSkin engineeringSkin tissue engineeringTesting platformsTissue engineering

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Polymers due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 16/90, thus managing to position itself as a Q1 (Primer Cuartil), in the category Polymer Science.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.07. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.2 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 4.27 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-09, the following number of citations:

  • WoS: 19
  • Scopus: 21
  • Europe PMC: 15

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-09:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 52 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Czech Republic.