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October 30, 2024
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Nitrate signaling promotes plant growth by upregulating gibberellin biosynthesis and destabilization of DELLA proteins

Publicated to: CURRENT BIOLOGY. 31 (22): 4971-+ - 2021-11-22 31(22), DOI: 10.1016/j.cub.2021.09.024

Authors:

Camut, L; Gallova, B; Jilli, L; Sirlin-Josserand, M; Carrera, E; Sakvarelidze-Achard, L; Ruffel, S; Krouk, G; Thomas, SG; Hedden, P; Phillips, AL; Davière, JM; Achard, P
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Affiliations

CSIC UPV, Inst Biol Mol & Celular Plantas - Author
Palacky Univ - Author
Rothamsted Res, Plant Sci Dept, Harpenden AL5 2JQ - Author
Univ Montpellier, BPMP, CNRS, INRAE,Montpellier SupAgro - Author
Univ Strasbourg, Inst Biol Mol Plantes, CNRS - Author
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Abstract

Nitrate, one of the main nitrogen (N) sources for crops, acts as a nutrient and key signaling molecule coordinating gene expression, metabolism, and various growth processes throughout the plant life cycle. It is widely accepted that nitrate-triggered developmental programs cooperate with hormone synthesis and transport to finely adapt plant architecture to N availability. Here, we report that nitrate, acting through its signaling pathway, promotes growth in Arabidopsis and wheat, in part by modulating the accumulation of gibberellin (GA)-regulated DELLA growth repressors. We show that nitrate reduces the abundance of DELLAs by increasing GA contents through activation of GA metabolism gene expression. Consistently, the growth restraint conferred by nitrate deficiency is partially rescued in global-DELLA mutant that lacks all DELLAs. At the cellular level, we show that nitrate enhances both cell proliferation and elongation in a DELLAdependent and-independent manner, respectively. Our findings establish a connection between nitrate and GA signaling pathways that allow plants to adapt their growth to nitrate availability.
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Keywords

AccumulationArabidopsisArabidopsis proteinArabidopsis proteinsArchitectureDella proteinsExpressionFrameworkGene expression regulationGene expression regulation, plantGeneticsGenomic analysisGibberellinGibberellinsGrowthHormone biosynthesisMetabolismModulationNitrateNitratesNitric acid derivativePathwayPhysiologyPhytohormonePlantPlant developmentPlant growth regulatorsPlant proteinPlant proteinsPlantsResponsesRht-1 dwarfing genesSignal transductionTransportWheat

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal CURRENT BIOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 3/94, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.42. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 10 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-02, the following number of citations:

  • WoS: 66
  • Scopus: 72
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 113.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 113 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 28.
  • The number of mentions on the social network X (formerly Twitter): 34 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Czech Republic; France; United Kingdom.

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