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October 31, 2024
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Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse

Publicated to: Angewandte Chemie (International ed. Print). 52 (25): 6476-6479 - 2013-01-01 52(25), DOI: 10.1002/anie.201302176

Authors:

Vendrell-Criado, V; Rodríguez-Muñiz, GM; Cuquerella, MC; Lhiaubet-Vallet, V; Miranda, MA
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Affiliations

Univ Politecn Valencia, CSIC, Inst Tecnol Quim - Author

Abstract

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Keywords

2-pyrimidinone nucleosides5 methyl 2 pyrimidinone5-methyl-2-pyrimidinoneAgarose gel electrophoresisAromatic compoundsArticleChromophoresCyclobutane pyrimidine dimerCyclobutane pyrimidine dimersDamageDnaDna damageDna damagesDrug effectDynamicsElectrophoresisMechanismMetabolismMutagenesisNucleic-acid componentsOxidative damagePhotochemical reactionsPhotochemical studiesPhotochemistryPhotolyasePhotoproductsPhotosensitizersPhotosensitizing agentPhotosensitizing agentsPyrimidine dimerPyrimidine dimersPyrimidinone derivativePyrimidinonesPyrimidonesRepairThymineTriplet excited statesTrojan horse

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Angewandte Chemie (International ed. Print) due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2013, it was in position 11/148, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 36
  • Scopus: 45
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 28 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Vendrell-Criado, V) and Last Author (Miranda, MA).

the author responsible for correspondence tasks has been Lhiaubet-Vallet, V.

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