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October 31, 2024
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The gibberellin precursor GA12 acts as a long-distance growth signal in Arabidopsis

Publicated to: Nature Plants. 1 (6): 15073- - 2015-06-01 1(6), DOI: 10.1038/NPLANTS.2015.73

Authors:

Regnault, T; Davière, JM; Wild, M; Sakvarelidze-Achard, L; Heintz, D; Bergua, EC; Diaz, IL; Gong, F; Hedden, P; Achard, P
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Affiliations

CSIC UPV, Inst Biol Mol & Celular Plantas - Author
Rothamsted Res, Harpenden AL5 2JQ - Author
Univ Strasbourg, UPR2357, Inst Biol Mol Plantes - Author
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Abstract

The gibberellin (GA) phytohormones play important roles in plant growth and development, promoting seed germination, elongation growth and reproductive development(1). Over the years, substantial progress has been made in understanding the regulation of GA signalling and metabolism, which ensures appropriate levels of GAs for growth and development(2). Moreover, an additional level of regulation may reside in the transport of GAs from production sites to recipient tissues that require GAs for growth. Although there is considerable evidence suggesting the existence of short- and long-distance movement of GAs in plants(3-8), the nature and the biological properties of this transport are not yet understood. Here, we combine biochemical and conventional micrografting experiments in Arabidopsis thaliana to show that the GA precursor GA(12), although biologically inactive by itself, is the major mobile GA signal over long distances. Quantitative analysis of endogenous GAs in xylem and phloem exudates further indicates that GA(12) moves through the plant vascular system. Finally, we demonstrate that GA(12) is functional in recipient tissues, supporting growth via the activation of the GA signalling cascade. Collectively, these results reveal the existence of long-range transport of endogenous GA(12) in plants that may have implications for the control of developmental phase transitions and the adaptation to adverse environments.
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Keywords

AuxinEnt-kaureneGenesHormonesOverlapping rolesPhloemRegulatorsRoot-growthSubstancesTransport

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nature Plants, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Plant Sciences, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.48. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.02 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-03, the following number of citations:

  • WoS: 110
  • Scopus: 119
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 181.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 181 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 15.
  • The number of mentions on the social network Facebook: 4 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 18 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France; United Kingdom.

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