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Analysis of institutional authors

Corma, AAuthor

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October 31, 2024
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Multifunctional hybrid materials for combined photo and chemotherapy of cancer

Publicated to: DALTON TRANSACTIONS. 41 (31): 9243-9554 - 2012-01-01 41(31), DOI: 10.1039/c2dt30381g

Authors:

Botella, Pablo; Ortega, Ilida; Quesada, Manuel; Madrigal, Roque F; Muniesa, Carlos; Fimia, Antonio; Fernandez, Eduardo; Corma, Avelino
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Affiliations

Univ Miguel Hernandez, Dept Ciencia Mat Opt & Tecnol Elect - Author
Univ Miguel Hernandez, SpainCtr Invest Biomed Red CIBER BBN, Inst Bioingn - Author
UPV CSIC, Inst Tecnol Quim - Author
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Abstract

Combined chemo and photothermal therapy in in vitro testing has been achieved by means of multifunctional nanoparticles formed by plasmonic gold nanoclusters with a protecting shell of porous silica that contains an antitumor drug. We propose a therapeutic nanoplatform that associates the optical activity of small gold nanoparticles aggregates with the cytotoxic activity of 20(S)-camptothecin simultaneously released for the efficient destruction of cancer cells. For this purpose, a method was used for the controlled assembly of gold nanoparticles into stable clusters with a tailored absorption cross-section in the vis/NIR spectrum, which involves aggregation in alkaline medium of 15 nm diameter gold colloids protected with a thin silica layer. Clusters were further encapsulated in an ordered homogeneous mesoporous silica coating that provides biocompatibility and stability in physiological fluids. After internalization in 42-MG-BA human glioma cells, these protected gold nanoclusters were able to produce effective photothermolysis under femtosecond pulse laser irradiation of 790 nm. Cell death occurred by combination of a thermal mechanism and mechanical disruption of the membrane cell due to induced generation of micrometer-scale bubbles by vaporizing the water inside the channels of the mesoporous silica coating. Moreover, the incorporation of 20(S)-camptothecin within the pores of the external shell, which was released during the process, provoked significant cell death increase. This therapeutic model could be of interest for application in the treatment and suppression of non-solid tumors.
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Keywords

Absorption cross-sectionAlkaline mediumAntineoplastic agentAntineoplastic agents, phytogenicAntitumor drugsArticleBiocompatibilityBody fluidsCamptothecinCamptothecin (cpt)Cancer cellsCell deathCell line, tumorCell survivalChemistryChemotherapyCoatingsCombined modality therapyControlled assemblyControlled drug-deliveryCytotoxic activitiesDrug effectElectromagnetic pulseFemtosecond pulse laserGlioma cellsGoldGold colloidGold compoundsGold nanoclusterGold nanoparticlesHeatHollow gold nanospheresHot temperatureHumanHumansHybrid materialsIn-vitroLaser surgeryLaser therapyLow level laser therapyMechanical disruptionMembrane cellsMesoporous silicaMesoporous silica nanoparticlesMetal nanoparticleMetal nanoparticlesMicrometer-scaleMicroscopy, electron, transmissionMulti-functional nanoparticlesMultimodality cancer therapyNeoplasmNeoplasmsNitrogen adsorptionOptical activityOptical-propertiesPhotothermal therapyPhotothermolysisPhysiological fluidsPlasmonicPlasmonic propertiesPorous silicaProtected gold nanoclustersRadiation exposureRapid colorimetric assaySelective nanophotothermolysisShape-controlled synthesisSilicaSilica layersSilicon dioxideStable clustersThermal mechanismsTransmission electron microscopyTumor cell lineTumorsUltrastructure

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal DALTON TRANSACTIONS due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 8/44, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Inorganic & Nuclear.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.8. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.66 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-02, the following number of citations:

  • WoS: 43
  • Scopus: 48
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 57.

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Botella, P) and Last Author (Corma Canós, Avelino).

the author responsible for correspondence tasks has been Botella, P.

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