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Llopis-Lorente, AntoniAuthor

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November 28, 2024
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Future Nanotechnology-Based Strategies for Improved Management of Helicobacter pylori Infection

Publicated to: Small. 20 (3): e2302532- - 2024-01-01 20(3), DOI: 10.1002/smll.202302532

Authors:

Kamankesh, Mojtaba; Yadegar, Abbas; Llopis-Lorente, Antoni; Liu, Chenguang; Haririan, Ismaeil; Aghdaei, Hamid Asadzadeh; Shokrgozar, Mohammad Ali; Zali, Mohammad Reza; Miri, Amir Hossein; Rad-Malekshahi, Mazda; Hamblin, Michael R; Wacker, Matthias G
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Affiliations

Natl Univ Singapore, Fac Sci, Dept Pharm, 4 Sci Dr 2, Singapore City 117544, Singapore - Author
Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China - Author
Pasteur Inst Iran, Natl Cell Bank Iran, Tehran 1316943551, Iran - Author
Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Basic & Mol Epidemiol Gastrointestinal Disorders, Res Ctr, Tehran 1985717411, Iran - Author
Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Foodborne & Waterborne Dis Res Ctr, Tehran 1985717411, Iran - Author
Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran 1985717411, Iran - Author
Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa - Author
Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Biomat, Tehran 1417614411, Iran - Author
Univ Tehran Med Sci, Fac Pharm, Med Biomat Res Ctr, Tehran 1417614411, Iran - Author
Univ Tehran, Sch Sci, Dept Polymer Chem, POB 14155-6455, Tehran, Iran - Author
Univ Valencia, Desarrollo Tecnol IDM Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol, Camino Vera S-N, Valencia 46022, Spain - Author
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Abstract

Helicobacter pylori (H. pylori) is a recalcitrant pathogen, which can cause gastric disorders. During the past decades, polypharmacy-based regimens, such as triple and quadruple therapies have been widely used against H. pylori. However, polyantibiotic therapies can disturb the host gastric/gut microbiota and lead to antibiotic resistance. Thus, simpler but more effective approaches should be developed. Here, some recent advances in nanostructured drug delivery systems to treat H. pylori infection are summarized. Also, for the first time, a drug release paradigm is proposed to prevent H. pylori antibiotic resistance along with an IVIVC model in order to connect the drug release profile with a reduction in bacterial colony counts. Then, local delivery systems including mucoadhesive, mucopenetrating, and cytoadhesive nanobiomaterials are discussed in the battle against H. pylori infection. Afterward, engineered delivery platforms including polymer-coated nanoemulsions and polymer-coated nanoliposomes are poposed. These bioinspired platforms can contain an antimicrobial agent enclosed within smart multifunctional nanoformulations. These bioplatforms can prevent the development of antibiotic resistance, as well as specifically killing H. pylori with no or only slight negative effects on the host gastrointestinal microbiota. Finally, the essential checkpoints that should be passed to confirm the potential effectiveness of anti-H. pylori nanosystems are discussed.
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Keywords

Anti-bacterial agentsAntibiotic resistanceAntibioticsAntibiotics resistanceAntiinfective agentAntimicrobial agentsBiomedical applicationsChitosan/heparin nanoparticlesCo-deliveryCombination drug therapyControlled drug deliveryDelivery systemsDrug releaseDrug resistance, bacterialDrug therapy, combinationDrug-delivery-systemsEpigallocatechin gallateExtracellular vesiclesGastrointestinal-tracH. pyloriHelicobacter infectionHelicobacter infectionsHelicobacter pyloriHelicobacter pylori infectionsHumanHumansIn-vivo correlationLocal deliveryLocal delivery systemLocal delivery systemsMetallic nanoparticlesMicrobiologyNanoformulationNanosystemsNanotechnologyOral deliveryPlastic coatingsPolymerPolymersPolypharmacySequential drug releasSequential drug releaseTargeted drug delivery

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Small due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 14/187, thus managing to position itself as a Q1 (Primer Cuartil), in the category Physics, Applied. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-03:

  • WoS: 11
  • Scopus: 16
  • Europe PMC: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: China; Iran; Singapore; South African Republic.

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Awards linked to the item

The authors would like to acknowledge Dr. Jyothi M. S. (Assistant Professor of AMC Engineering College, Bengaluru, India) for supplying some experimental data to develop a novel IVIVC model. Also, the authors gratefully acknowledge Mr. Misagh Fathi Kisomi for redrawing some copyright figures with high resolution. Moreover, the authors sincerely apologize to all researchers who have published on pathogenesis and pharmacotherapy of H. pylori infection during the last decade, whom the authors could not cite in this extensive review.
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