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This research was supported by Institut de Salud Carlos III grant FIS (FI 060944 953/2006).

Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Almudéver-Folch, PatriciaAuthor

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Article

Quantification of nortriptyline in plasma by HPLC and fluorescence detection

Publicated to:Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences. 878 (9-10): 841-844 - 2010-03-15 878(9-10), DOI: 10.1016/j.jchromb.2010.01.033

Authors: Almudever, Patricia; Peris, Jose-Esteban; Garrigues, Teresa; Diez, Octavio; Melero, Ana; Alos, Manuel

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Abstract

A simple, sensitive and specific high-performance liquid chromatography method has been developed for the determination of nortriptyline (NT) in plasma samples. The assay involved derivatization with 9H-fluoren-9-ylmethyl chloroformate (Fmoc-Cl) and isocratic reversed-phase (C-18) chromatography with fluorescence detection. The developed method required only 100 mu l of plasma sample, deproteinized and derivatized in one step. Calibration curves were lineal over the concentration range of 5-5000 ng/ml. The derivatization reaction was performed at room temperature in 20 min and the obtained NT derivative was stable for at least 48 h at room temperature. The within-day and between-day relative standard deviation was below 8%. The limit of detection (LOD) was 2 ng/ml, and the lower limit of quantification (LLOQ) was established at 10 ng/ml. The method was applied on plasma collected from rats, at different time intervals, after intravenous administration of 0.5 mg of NT. (C) 2010 Elsevier B.V. All rights reserved.

Keywords

AnimalsAntidepressive agentsAntipsychoticChromatography, high pressure liquidDerivatizationDrugsFmoc chlorideGood health and well-beingHplHplcHuman serumHumansLimit of detectionNortriptylinePerformance liquid-chromatographyRatsSolid-phase extractionTandem mass-spectrometryTricyclic antidepressantsWhole-blood

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position 17/73, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Analytical.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.04, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-06, the following number of citations:

  • WoS: 15
  • Scopus: 16
  • Europe PMC: 7
  • OpenCitations: 14

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 18 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 0% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Almudéver Folch, Patricia) .