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This work was supported by project PID2021-126304OB-C41 funded by MCIN/AEI/10.13039/501100011033/and by European Regional Development Fund - A way of doing Europe and Generalitat Valenciana (project CIPROM/2021/007) and CIBER (CB07/01/2012). There has also been the support of Institute of Health Carlos III (COV20/01209, Ministry of Science and Innovation of Spain) and grants from the Valencian Society of Pulmonology (FNCV Grant 2022 IP: Lucia Fernandez Presa; FNCV Grant Coordinated Research Project 2022 IP: Jaime Signes-Costa), U26 NMR: Biomedical Applications II platform from Nanbiosis (Research Infrastructures & Services of CIBER-BBN) and Marina Botello - Marabotto PhD grant (FPU 2020) from Spanish' government.

Analysis of institutional authors

Martínez Mañez, RamónAuthorBernardos, AndreaAuthor

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April 14, 2025
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Metabolomic Biomarkers of Pulmonary Fibrosis in COVID-19 Patients One Year After Hospital Discharge

Publicated to:Journal Of Medical Virology. 97 (3): e70289- - 2025-03-01 97(3), DOI: 10.1002/jmv.70289

Authors: Botello-Marabotto, Marina; Tarraso, Julia; Mulet, Alba; Presa-Fernandez, Lucia; Fernandez-Fabrellas, Estrella; Portal, Jose A Rodriguez; Ros, Jose A; Lozano-Vicente, Desire; Bernardos, Andrea; Martinez-Bisbal, M Carmen; Martinez-Manez, Ramon; Signes-Costa, Jaime

Affiliations

Hosp Arcos Mar del Menor, Pulm Dept, Murcia, Spain - Author
Hosp Gen Valencia, Pulm Dept, Valencia, Spain - Author
Hosp Virgen Arrixaca, Pulm Dept, Murcia, Spain - Author
Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Madrid, Spain - Author
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia, Spain - Author
Univ Politecn Valencia, Dept Quim, Valencia, Spain - Author
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria La Fe IISLAFE, Valencia, Spain - Author
Univ Seville, Hosp Virgen Rocio, Seville, Spain - Author
Univ Valencia, Dept Quim Fis, Valencia, Spain - Author
Univ Valencia, Hosp Clin, Pulm Dept, INCLIVA, Valencia, Spain - Author
Univ Valencia, Univ Politecn Valencia, Inst Interuniv Invest Reconocimiento Mol & Desarro, Valencia, Spain - Author
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Abstract

Coronavirus disease 2019 (COVID-19) global pandemic has affected more than 600 million people up to date. The symptomatology and severity of COVID-19 are very broad, and there are still concerns about the long-term sequelae that it can have on discharged patients. The development of pulmonary fibrotic sequelae after this infection is especially worrying. Our aim was to determine if there was a metabolomic signature that could predict the development of pulmonary fibrotic sequelae. It is a multicenter prospective observation subcohort based on the COVID-FIBROTIC study. A metabolomic analysis was performed by nuclear magnetic resonance (NMR) on serum samples from patients admitted with bilateral COVID-19 pneumonia collected 2 months after hospital discharge. One year after admission, clinical, functional and radiological data were collected from these same patients. Finally, 109 patients (mean age 57.68 [DS14.03], 65.13% male) were available. Fibrotic sequelae 1 year after COVID-19 disease were found in 33% of them. Based on the NMR analysis of the serum samples, it was possible to distinguish with 80.82% of sensitivity, 72.22% of specificity and 0.83 of an area under the curve (AUC) value which patients would have radiological signs of pulmonary fibrotic pattern 1 year after sample collection. According to the metabolites participating in the discriminative model and the univariate statistics, glucose, valine, and fatty acids (& boxH;CH-CH2-CH & boxH;) were suggested as potential biomarkers of the development of pulmonary fibrotic sequelae after COVID-19.

Keywords

1h‐nmr spectroscopyAdultAgedBiomarkersCovid-19Covid‐19FemaleH-1-nmr spectroscopyHumansMagnetic resonance spectroscopyMaleMetabolomicsMiddle agedPatient dischargeProspective studiesPulmonary fibrosiPulmonary fibrosisSars-cov-2SocietSpectroscopySpirometry

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Medical Virology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 7/42, thus managing to position itself as a Q1 (Primer Cuartil), in the category Virology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 3.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 3 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.35.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Botello-Marabotto, Marina) .

the author responsible for correspondence tasks has been Martinez-Bisbal, M Carmen.