{rfName}
Ba

License and Use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Alvarez, VAuthorEsteve, RAuthorToledo, J FAuthor

Share

December 4, 2025
Publications
>
Article

Barium ion sensing with IPG K+ molecular probes

Publicated to: ANALYST. 150 (24): 5558-5567 - 2025-12-01 150(24), DOI: 10.1039/d5an00577a

Authors:

Miller, RL; Byrnes, N; Cameron, CG; Carlson, AJ; Dey, E; Madigan, R; Medina, J; Melancon, S; Navarro, KE; Foss, FW; Jones, BJP; Adams, C; Almazán, H; Alvarez, V; Aranburu, AI; Arazi, L; Arnquist, IJ; Auria-Luna, F; Ayet, S; Azevedo, CDR; Bailey, K; Ballester, F; Barcelon, JE; del Barrio-Torregrosa, M; Bayo, A; Benlloch-Rodriguez, JM; Borges, FIGM; Brodolin, A; Castillo, A; Church, E; Cid, L; Conde, CAN; Cortes-Parra, C; Cossío, FP; Coupe, R; Dietz, P; Echevarria, C; Elorza, M; Esteve, R; Felkai, R; Fernandes, LMP; Ferrario, P; Freixa, Z; García-Barrena, J; Gomez-Cadenas, JJ; Grocott, JWR; Guenette, R; Hauptman, J; Henriques, CAO; Morata, JAH; Herrero-Gomez, P; Herrero, V; Carrete, CH; Ifergan, Y; Kellerer, F; Larizgoitia, L; Larumbe, A; Lebrun, P; Lopez, F; Lopez-March, N; Mano, RDP; Marauri, A; Marques, AP; Martín-Albo, J; Martínez, A; Martínez-Lema, G; Martínez-Vara, M; Mistry, K; Molina-Canteras, J; Monrabal, F; Monteiro, CMB; Mora, FJ; Novella, P; Nygren, DR; Oblak, E; Palacio, J; Palmeiro, B; Para, A; Parmaksiz, I; Pazos, A; Pelegrin, J; Maneiro, MP; Querol, M; Renner, J; Rivilla, I; Rogero, C; Rogers, L; Romeo, B; Romo-Luque, C; Ruiz-Choliz, E; Saharia, P; Santos, FP; Dos Santos, JMF; Seemann, M; Shomroni, I; Silva, ALM; Silva, PAOC; Simon, A; Soleti, SR; Sorel, M; Soto-Oton, J; Teixeira, JMR; Teruel-Pardo, S; Toledo, JF; Tonnelé, C; Torelli, S; Torrent, J; Trettin, A; Valle, PRG; Vanga, M; Veloso, JFCA; Villamil, JD; Waiton, J; Yubero-Navarro, A
[+]

Affiliations

Argonne Natl Lab, Argonne, IL 60439 USA - Author
Basque Fdn Sci, Ikerbasque, E-48009 Bilbao, Spain - Author
Ben Gurion Univ Negev, Fac Engn Sci, Unit Nucl Engn, POB 653, IL-8410501 Beer Sheva, Israel - Author
BERC Basque Excellence Res Ctr, Donostia Int Phys Ctr, Manuel Lardizabal 4, E-20018 San Sebastian, Spain - Author
CSIC, Ctr Fis Mat CFM, Manuel Lardizabal 5, E-20018 Donostia San Sebastian, Spain - Author
Fermilab Natl Accelerator Lab, Batavia, IL 60510 USA - Author
Hebrew Univ Jerusalem, Racah Inst Phys, IL-9190401 Jerusalem, Israel - Author
Iowa State Univ, Dept Phys & Astron, Ames, IA 50011 USA - Author
Lab Subterraneo Canfranc, Paseo Ayerbe S-N, Canfranc Estn 22880, Spain - Author
Los Alamos Natl Lab, Los Alamos, NM USA - Author
NVIDIA, Santa Clara, CA USA - Author
Pacific Northwest Natl Lab PNNL, Richland, WA 99352 USA - Author
Univ Aveiro, Inst Nanostruct Nanomodelling & Nanofabricat I3N, Campus Univ Santiago, P-3810193 Aveiro, Portugal - Author
Univ Coimbra, Dept Phys, LIP, P-3004516 Coimbra, Portugal - Author
Univ Coimbra, Phys Dept, LIBPhys, Rua Larga, P-3004516 Coimbra, Portugal - Author
Univ Girona, Escola Politecn Super, Campus Montilivi S-N, E-17071 Girona, Spain - Author
Univ Manchester, Dept Phys & Astron, Manchester M13 9PL, England - Author
Univ North Carolina, Chapel Hill, NC USA - Author
Univ Pais Vasco UPV EHU, Ctr Innovac Quim Avanzada ORFEO CINQA, Dept Organ Chem 1, E-20018 San Sebastian, Donostia, Spain - Author
Univ Pais Vasco UPV EHU, Dept Organ Chem 1, Manuel Lardizabal Ibilbidea 3, Donostia San Sebastian 20018, Spain - Author
Univ Pais Vasco UPV EHU, Dept Phys, POB 644, E-48080 Bilbao, Spain - Author
Univ Pais Vasco UPV EHU, Manuel Lardizabal 5, E-20018 Donostia San Sebastian, Spain - Author
Univ Politecn Valencia, Ctr Mixto CSIC, Inst Instrumentac Imagen Mol I3M, Camino Vera S-N, E-46022 Valencia, Spain - Author
Univ Santiago Compostela, Inst Gallego Fis Altas Energias, Campus Sur,Rua Xose Maria Suarez Nunez S-N, E-15782 Santiago De Compostela, Spain - Author
Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA - Author
Univ Texas Arlington, Dept Phys, Arlington, TX 76019 USA - Author
Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Calle Catedrat Jose Beltran 2, E-46980 Paterna, Spain - Author
Weizmann Inst Sci, Rehovot, Israel - Author
See more

Abstract

Fluorophores covalently bound to azacrown ether ionophores can be assembled into sensitive turn-on chemosensors. The size specificity and electron-rich nature of the ionophore's binding domain contribute to both selectivity and strong turn-on fluorescence sensing by various mechanisms when properly constructed. Aza-18-crown-6 ethers are quite selective for binding to K+ and Ba2+, yet the more electron-withdrawing dicationic nature of barium imposes a larger electronic effect on turn-on fluorescent sensors. Barium chemosensors can be important for measuring soluble Ba2+ in drinking water and have gained recent attention for their potential to enhance the detection of rare events in xenon decay. Here we quantify the capability of three chemosensors, marketed for biologically useful K+ sensing, as effective probes for Ba2+ ions. We present measurements from bulk spectrofluorometry to characterize the system in aqueous solutions and demonstrate the usefulness of these species for low-background single-ion fluorescence microscopy, revealing new candidates for Ba2+ sensing.
[+]

Keywords

Ba2+CalciumEthersFluorescenceMercuryPotassiumSensor

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ANALYST due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 41/111, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Chemistry, Analytical. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Analytical Chemistry.

[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 2.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 2 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Eire; Israel; Jerusalem; Portugal; United Kingdom; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Yubero-Navarro, A).

[+]

Awards linked to the item

Our program of single metal ion sensing is a part of a collaborative project to employ SMFI chemosensors functional at the solid-gas interface as R&D toward barium tagging for the NEXT experiment. We thank ION Biosciences for supplying the IPG dyes used in these experiments and also for technical support on their best use. We acknowledge support from the US National Science Foundation under award number NSF CHE 2004111 and the Robert A Welch Foundation under award number Y-2031-20200401 (University of Texas Arlington) and the US Department of Energy under awards DE-SC0019054 and DE-SC0019223. The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under Grant Agreement No. 951281-BOLD; the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014-2020) under Grant Agreement No. 957202-HIDDEN; the MCIN/AEI of Spain and ERDF A way of making Europe under grants RTI2018-095979 and PID2021-125475NB, the Severo Ochoa Program grant CEX2018-000867-S and the Ramon y Cajal program grant RYC-2015-18820; the Generalitat Valenciana of Spain under grants PROMETEO/2021/087 and CIDEGENT/2019/049; the Department of Education of the Basque Government of Spain under the predoctoral training program non-doctoral research personnel; the Portuguese FCT under project UID/FIS/04559/2020 to fund the activities of LIBPhys-UC; the Pazy Foundation (Israel) under grants 877040 and 877041; the US Department of Energy under contracts number DE-AC02-06CH11357 (Argonne National Laboratory) and DE-AC02-07CH11359 (Fermi National Accelerator Laboratory). Finally, we are grateful to the Laboratorio Subterraneo de Canfranc for hosting and supporting the NEXT experiment.
[+]