Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Publicated to:Journal Of Extracellular Vesicles. 7 (1): 1535750- - 2018-11-23 7(1), DOI: 10.1080/20013078.2018.1535750

Authors: Thery, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Jose Alcaraz, Maria; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K; Ayre, D Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N; Baxter, Amy A; Bebawy, Mary; Beckham, Carla; Zavec, Apolonija Bedina; Benmoussa, Abderrahim; Berardi, Anna C; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borras, Francesc E; Bosch, Steffi; Boulanger, Chantal M; Breakefield, Xandra; Breglio, Andrew M; Brennan, Meadhbh A; Brigstock, David R; Brisson, Alain; Broekman, Marike L D; Bromberg, Jacqueline F; Bryl-Gorecka, Paulina; Buch, Shilpa; Buck, Amy H; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzas, Edit, I; Byrd, James Bryan; Camussi, Giovanni; Carter, David R F; Caruso, Sarah; Chamley, Lawrence W; Chang, Yu-Ting; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R; Clayton, Aled; Clerici, Stefano P; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank A W; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D'Souza-Schorey, Crislyn; Das, Saumya; Chaudhuri, Amrita Datta; de Candia, Paola; De Santana Junior, Eliezer F; De Wever, Olivier; del Portillo, Hernando A; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R; Driedonks, Tom A P; Duarte, Filipe, V; Duncan, Heather M; Eichenberger, Ramon M; Ekstrom, Karin; Andaloussi, Samir E L; Elie-Caille, Celine; Erdbrugger, Uta; Falcon-Perez, Juan M; Fatima, Farah; Fish, Jason E; Flores-Bellver, Miguel; Forsonits, Andras; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gamez-Valero, Ana; Gardiner, Chris; Gaertner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah C, I; Goergens, Andre; Gorski, Sharon M; Greening, David W; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F; Hochberg, Fred H; Hoffmann, Karl F; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K; Jacobsen, Soren; Jay, Steven M; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M; Jones, Jennifer C; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J, II; Kornek, Miroslaw; Kosanovic, Maja M; Kovacs, Arpad Ferenc; Kraemer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor, V; Kusuma, Gina D; Kuypers, Soren; Laitinen, Saara; Langevin, Scott M; Languino, Lucia R; Lannigan, Joanne; Lasser, Cecilia; Laurent, Louise C; Lavieu, Gregory; Lazaro-Ibanez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac T S; Liao, Ke; Libregts, Sten F; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Line, Aija; Linnemannstoens, Karen; Llorente, Alicia; Lombard, Catherine A; Lorenowicz, Magdalena J; Lorincz, Akos M; Lotvall, Jan; Lovett, Jason; Lowry, Michelle C; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R; Maas, Sybren L N; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S; Martin-Jaular, Lorena; Martinez, M Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; McGinnis, Lynda K; McVey, Mark J; Meckes, David G, Jr; Meehan, Katie L; Mertens, Inge; Minciacchi, Valentina R; Moller, Andreas; Jorgensen, Malene Moller; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, Francois; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C; Myburgh, Kathryn H; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P; Nolte-'t Hoen, Esther N M; Noren Hooten, Nicole; O'Driscoll, Lorraine; O'Grady, Tina; O'Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A; Osteikoetxea, Xabier; Ostegaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D Michiel; Peinado, Hector; Perut, Francesca; Pfaffl, Michael W; Phinney, Donald G; Pieters, Bartijn C H; Pink, Ryan C; Pisetsky, David S; von Strandmann, Elke Pogge; Polakovicova, Iva; Poon, Ivan K H; Powell, Bonita H; Prada, Ilaria; Pulliam, Lynn; Quesenberry, Peter; Radeghieri, Annalisa; Raffai, Robert L; Raimondo, Stefania; Rak, Janusz; Ramirez, Marcel, I; Raposo, Graca; Rayyan, Morsi S; Regev-Rudzki, Neta; Ricklefs, Franz L; Robbins, Paul D; Roberts, David D; Rodrigues, Silvia C; Rohde, Eva; Rome, Sophie; Rouschop, Kasper M A; Rughetti, Aurelia; Russell, Ashley E; Saa, Paula; Sahoo, Susmita; Salas-Huenuleo, Edison; Sanchez, Catherine; Saugstad, Julie A; Saul, Meike J; Schiffelers, Raymond M; Schneider, Raphael; Schoyen, Tine Hiorth; Scott, Aaron; Shahaj, Eriomina; Sharma, Shivani; Shatnyeva, Olga; Shekari, Faezeh; Shelke, Ganesh Vilas; Shetty, Ashok K; Shiba, Kiyotaka; Siljander, Pia R-M; Silva, Andreia M; Skowronek, Agata; Snyder, Orman L, II; Soares, Rodrigo Pedro; Sodar, Barbara W; Soekmadji, Carolina; Sotillo, Javier; Stahl, Philip D; Stoorvogel, Willem; Stott, Shannon L; Strasser, Erwin F; Swift, Simon; Tahara, Hidetoshi; Tewari, Muneesh; Timms, Kate; Tiwari, Swasti; Tixeira, Rochelle; Tkach, Mercedes; Toh, Wei Seong; Tomasini, Richard; Torrecilhas, Ana Claudia; Pablo Tosar, Juan; Toxavidis, Vasilis; Urbanelli, Lorena; Vader, Pieter; van Balkom, Bas W M; van der Grein, Susanne G; Van Deun, Jan; van Herwijnen, Martijn J C; Van Keuren-Jensen, Kendall; van Niel, Guillaume; van Royen, Martin E; van Wijnen, Andre J; Helena Vasconcelos, M; Vechetti, Ivan J, Jr; Veit, Tiago D; Vella, Laura J; Velot, Emilie; Verweij, Frederik J; Vestad, Beate; Vinas, Jose L; Visnovitz, Tamas; Vukman, Krisztina V; Wahlgren, Jessica; Watson, Dionysios C; Wauben, Marca H M; Weaver, Alissa; Webber, Jason P; Weber, Viktoria; Wehman, Ann M; Weiss, Daniel J; Welsh, Joshua A; Wendt, Sebastian; Wheelock, Asa M; Wiener, Zoltan; Witte, Leonie; Wolfram, Joy; Xagorari, Angeliki; Xander, Patricia; Xu, Jing; Yan, Xiaomei; Yanez-Mo, Maria; Yin, Hang; Yuana, Yuana; Zappulli, Valentina; Zarubova, Jana; Zekas, Vytautas; Zhang, Jian-ye; Zhao, Zezhou; Zheng, Lei; Zheutlin, Alexander R; Zickler, Antje M; Zimmermann, Pascale; Zivkovic, Angela M; Zocco, Davide; Zuba-Surma, Ewa K

Affiliations

Aalborg Univ Hosp, Dept Clin Biochem, Aalborg, Denmark - Author

Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark - Author

Aalborg Univ, Clin Inst, Aalborg, Denmark - Author

Aarhus Univ, Dept Clin Med, Aarhus, Denmark - Author

Aberystwyth Univ, IBERS, Aberystwyth, Dyfed, Wales - Author

AC Camargo Canc Ctr, Sao Paulo, Brazil - Author

Acad Med Ctr Univ Amsterdam, Dept Clin Chem, Amsterdam, Netherlands - Author

Acad Med Ctr Univ Amsterdam, Vesicle Observat Ctr, Amsterdam, Netherlands - Author

Academic Medical Centre, University of Amsterdam - Author

Adv Ctr Chron Dis, Santiago, Chile - Author

Aix Marseille Univ, Ctr Rech Cancerol Marseille, Inst Paoli Calmettes, INSERM U1068,CNRS UMR7258, Marseille, France - Author

Amer Red Cross, Sci Affairs, Gaithersburg, MD USA - Author

Aston Univ, Sch Life & Hlth Sci, Birmingham, W Midlands, England - Author

Aston University - Author

AstraZeneca, Discovery Sci, IMED Biotech Unit, Cambridge, England - Author

AstraZeneca, Discovery Sci, IMED Biotech Unit, Gothenburg, Sweden - Author

Atlantic Canc Res Inst, Moncton, NB, Canada - Author

Atlantic Cancer Research Institute - Author

BC Canc, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada - Author

Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA - Author

Boston Univ, Sch Med, Boston, MA 02118 USA - Author

Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, 75 Francis St, Boston, MA 02115 USA - Author

Brigham and Women's Hospital - Author

Brown Univ, Women & Infants Hosp, Providence, RI USA - Author

Canc Res Inst Ghent, Ghent, Belgium - Author

Cancer Research Institute Ghent - Author

Cardiff Univ, Sch Med, Cardiff, S Glam, Wales - Author

Cardiff University - Author

Case Western Reserve Univ, Dept Med, Cleveland, OH USA - Author

Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA - Author

Cedars Sinai Med Ctr, Smidt Heart Inst, Los Angeles, CA 90048 USA - Author

Cedars-Sinai Medical Center - Author

Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA - Author

Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou, Peoples R China - Author

CIBERehd, CIC bioGUNE, Exosomes Lab & Metabol Platform, Derio, Spain - Author

CIC bioGUNE - Author

Cincinnati Canc Ctr, Cincinnati, OH USA - Author

City Hope Comprehens Canc Ctr, Beckman Res Inst, Dept Mol Med, Duarte, CA USA - Author

Clin Las Condes, Extracellular Vesicles Personalized Med Grp, Santiago, Chile - Author

CNC, Coimbra, Portugal - Author

CNR, Inst Neurosci, Milan, Italy - Author

CSGI - Research Center for Colloids and Nanoscience - Author

CSGI Res Ctr Colloids & Nanosci, Florence, Italy - Author

Deutsches Zentrum fur Neurodegenerative Erkrankungen e.V. - Author

ETH Zürich - Author

Evox Therapeutics Limited - Author

Exogenus Therapeutics - Author

Germans Trias i Pujol Research Institute (PMPPC-IGTP) - Author

Haaglanden Medical Center - Author

Harvard Medical School - Author

Harvard University - Author

Hospital Universitari Germans Trias i Pujol - Author

Icahn School of Medicine at Mount Sinai - Author

Ikerbasque, the Basque Foundation for Science - Author

Immunite et Cancer - Author

INSERM - Author

INSERM, Ctr Psychiat & Neurosci, U894, Paris, France - Author

Inst Invest Sanitaria Princesa IIS IP, Ctr Biol Mol Severo Ochoa, Madrid, Spain - Author

Institució Catalana de Recerca i Estudis Avançats - Author

Instituto de Salud Global de Barcelona - Author

INSTM - National Interuniversity Consortium of Materials Science and Technology - Author

IRCCS Multimedica - Author

Istituto Di Biomedicina Ed Immunologia Molecolare Alberto Monroy - Author

JAMES COOK UNIVERSITY, AUSTRALIA - Author

JFCR, Canc Inst, Tokyo, Japan - Author

Karolinska Institutet - Author

Kidney Research Centre - Author

La Trobe University - Author

Leiden University Medical Center - LUMC - Author

Lunds universitet - Author

Research Institute for the Biology of Farm Animals - Author

Rigshosp, Copenhagen Lupus & Vasculitis Clin, Sect 4242, Copenhagen, Denmark - Author

Stress Oxydant et Pathologies Metaboliques - Author

Sysmex Co, Cent Res Labs, Kobe, Hyogo, Japan - Author

Univ Amsterdam, Dept Pathol, Med Ctr, Amsterdam, Netherlands - Author

Universite de Technologie Belfort-Montbeliard - Author

Universiteit Gent - Author

University Hospital of Ghent - Author

University of Valencia - Author

Uniwersytet Jagiellonski w Krakowie - Author

Abstract

Keywords

ectosomesexosomesextracellular vesiclesguidelinesmicroparticlesmicrovesiclesminimal information requirementsreproducibilityrigorCell-derived microparticlesCirculating microparticlesEctosomesExosomesExtracellular vesiclesFetal bovineField-flow fractionationGuidelinesHuman urinary exosomesMembrane-vesiclesMicroparticlesMicrovesiclesMinimal information requirementsPreanalytical parametersProstate-cancerReproducibilityRigorSize-exclusion chromatographyStandardizationSurface-plasmon resonance

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Extracellular Vesicles due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 16/193, thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology. Notably, the journal is positioned above the 90th percentile.

This publication has been distinguished as a “Highly Cited Paper” by the agencies WoS (ESI, Clarivate) and ESI (Clarivate), meaning that it ranks within the top 1% of the most cited articles in its thematic field during the year of its publication. In terms of the observed impact of the contribution, this work is considered one of the most influential worldwide, as it is recognized as highly cited. (source consulted: ESI Nov 14, 2024)

And this is evidenced by the extremely high normalized impacts through some of the main indicators of this type, which, although dynamic over time and dependent on the set of average global citations at the time of calculation, already indicate that they are well above the average in different agencies:

Normalization of citations relative to the expected citation rate (ESI) by the Clarivate agency: 146.58 (source consulted: ESI Nov 14, 2024)
Field Citation Ratio (FCR) from Dimensions: 928.24 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-28, the following number of citations:

WoS: 6734
Europe PMC: 3186
Google Scholar: 5483

Impact and social visibility

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina; Australia; Austria; Belgium; Brazil; Canada; Chile; China; Czech Republic; Denmark; Finland; France; Gambia; Germany; Gran Bretanya; Greece; Hungary; India; Iran; Israel; Italy; Japan; Latvia; Lithuania; Malt; Netherlands; New Zealand; Norway; Poland; Portugal; Republic of Korea; Russia; Serbia; Singapore; Slovenia; South African Republic; Sweden; Switzerland; Taiwan; Turkey; United Kingdom; United States of America; Uruguay.

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Affiliations

Abstract

Keywords

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Impact and social visibility

Leadership analysis of institutional authors