The present study addresses the influences of wind flow structure, as an important factor responsible of material damage (erosion contributing) on "Casa di Diana" Mithraeum, a roman building (130 A.D.) sited on Ostia Antica (archaeological site, Rome - Italy), through the Computational Fluid Dynamics (CFD) simulations and direct measurements for its verification and validation (V&V). In this preliminary work, we present results relating to 3D reconstruction (geometry of the entire building) and the mesh importing on Fluent software. In general, the data check confirms, with +/- 10%, a good agreement (model) between the numerical solutions and direct measurements data by portable sensor. For this, the model proposed could be applied on similar cases, buildings characterised by different "boundary conditions", to predict without direct measurements, the air movement in these ventilated spaces.