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Analysis of institutional authors

Viteri-Echeverría, JAuthorAndres, AAuthorHeredia, AAuthorGarcía-Hernández, JAuthor

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October 11, 2024
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In vitro screening of the impact of dietary prebiotic components, probiotic strains, and their symbiotic combinations on colonic microbiota in children with cystic fibrosis

Publicated to:Food & Function. 15 (12): 6512-6522 - 2024-06-17 15(12), DOI: 10.1039/d4fo00325j

Authors: Viteri-Echeverria, Jazmin; Andres, Ana; Calvo-Lerma, Joaquim; Heredia, Ana; Garcia-Hernandez, Jorge; Asensio-Grau, Andrea

Affiliations

Facultad De Ciencias De La Salud. Universidad Internacional de Valencia - Author
Univ Inst Food Engn FoodUPV, Polytech Univ Valencia, Camino Vera S-N - Author
Univ Politecn Valencia, Adv Food Microbiol Ctr CAMA, Camino Vera S-N - Author
Univ Valencia, Res Grp Innovat Technol Sustainable Food ALISOST, Avda Vicent Andres Estelles S-N - Author

Abstract

Children with Cystic Fibrosis (CF) are more likely to have intestinal dysbiosis due to recurrent antibiotic therapy and the conventional hypercaloric diet administered to them. This study aimed at evaluating the effect of isolated prebiotic components and probiotic strains, and their combinations as potential synbiotics, on the intestinal microbiota of CF children. A static in vitro colonic fermentation model was used by colonizing vials with faecal inoculum, a culture medium, and the substrates to be tested. Post treatment, aliquots were taken to determine ammonium, lactate, and short-chain fatty acids production and to profile the microbiota composition by 16s rRNA sequencing. At genus level, Escherichia-Shigella decreased (15.8%) with the treatment pectin + L. rhamnosus, followed by the beta-glucan + L. salivarius (15.5%). Inversely, the most increase in Bacteroides (44%) was obtained by the treatment with Pectin + L. reuteri. Lactate and acetic acid production was significantly increased with prebiotics and their combinations with L. rhamnosus and L. salivarius. In conclusion, the use of beta-glucan and pectin in combination with probiotic strains from the Lactobacillaceae family suggest potential to modulate dysbiosis and metabolic activity on CF colonic microbiota, encouraging further studies in animal studies or clinical settings to confirm the findings in vivo.

Keywords

BacteriaChildColonCystic fibrosisDysbiosisFatty acids, volatileFecesFemaleFermentationGastrointestinal microbiomeHumansMalePectinsPrebioticsProbiotics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Food & Function due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 63/313, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-18:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 17 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Viteri Echeverría, Jazmín Dayumara) and Last Author (Asensio-Grau, A).

the author responsible for correspondence tasks has been Asensio-Grau, A.