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Analysis of institutional authors

Escudero, AAuthorMurguia, JrAuthorMartí-Centelles, VAuthorMartínez-Máñez, RCorresponding Author

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October 28, 2024
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Ficin-Cyclodextrin-Based Docking Nanoarchitectonics of Self-Propelled Nanomotors for Bacterial Biofilm Eradication

Publicated to:Chemistry Of Materials. 35 (11): 4412-4426 - 2023-05-09 35(11), DOI: 10.1021/acs.chemmater.3c00587

Authors: Ziemyte, Migle; Escudero, Andrea; Diez, Paula; Ferrer, Maria D; Murguia, Jose R; Marti-Centelles, Vicente; Mira, Alex; Martinez-Manez, Ramon

Affiliations

FISABIO Fdn, Genom & Hlth Dept - Author
Inst Carlos III, CIBER Epidemiol & Publ Hlth CIBERESP - Author
Univ Politecn Valencia, Ctr Invest Principe Felipe, Unidad Mixta UPV CIPF Invest Mecanismos Enfermedad, Valencia 46012 - Author
Univ Politecn Valencia, Dept Quim - Author
Univ Politecn Valencia, Unidad Mixta Invest Nanomed & Sensores, Inst Invest Sanitaria Fe - Author
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Abstract

Development of bioinspired nanomotors showing effective propulsion and cargo delivery capabilities has attracted much attention in the last few years due to their potential use in biomedical applications. However, implementation of this tech-nology in realistic settings is still a barely explored field. Herein, we report the design and application of a multifunctional gated Janus platinum-mesoporous silica nanomotor constituted of a propelling element (platinum nanodendrites) and a drug-loaded nano-container (mesoporous silica nanoparticle) capped with ficin enzyme modified with beta-cyclodextrins (beta-CD). The engineered nanomotor is designed to effectively disrupt bacterial biofilms via H2O2-induced self-propelled motion, ficin hydrolysis of the extracellular polymeric matrix (EPS) of the biofilm, and controlled pH-triggered cargo (vancomycin) delivery. The effective synergic antimicrobial activity of the nanomotor is demonstrated in the elimination of Staphylococcus aureus biofilms. The nanomotor achieves 82% of EPS biomass disruption and a 96% reduction in cell viability, which contrasts with a remarkably lower reduction in biofilm elimination when the components of the nanomotors are used separately at the same concentrations. Such a large reduction in biofilm biomass in S. aureus has never been achieved previously by any conventional therapy. The strategy proposed suggests that engineered nanomotors have great potential for the elimination of biofilms.

Keywords

% reductionsBacteriaBacterial biofilmBenzimidazoleBiofilmsBiomedical applicationsCargo deliveryControlled drug deliveryCyclodextrinsDesign and applicationMechanismsMedical applicationsMesoporous silica nanoparticlesMesoporous silicasMicromotorsMotionNanocontainersNanodendritesNanomotorsNanoparticlesPlatinumPropulsionQuantificationSilica nanoparticlesTargeted drug delivery

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Chemistry Of Materials due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 85/439, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Multidisciplinary.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.81. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.17 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 7.78 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-27, the following number of citations:

  • WoS: 18
  • Scopus: 15
  • Europe PMC: 9

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 38 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 18.
  • The number of mentions on the social network X (formerly Twitter): 14 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Martínez Mañez, Ramón).

the authors responsible for correspondence tasks have been Díez, P, Mira, A and Martínez Mañez, Ramón.