{rfName}
Ph

Indexed in

License and use

Citations

230

Altmetrics

Analysis of institutional authors

Carceller, JmAuthor

Share

October 28, 2024
Publications
>
Review
No

Photobiocatalytic Strategies for Organic Synthesis

Publicated to:Chemical Reviews. 123 (9): 5459-5520 - 2023-05-10 123(9), DOI: 10.1021/acs.chemrev.2c00767

Authors: Emmanuel, Megan A; Bender, Sophie G; Bilodeau, Catherine; Carceller, Jose M; DeHovitz, Jacob S; Fu, Haigen; Liu, Yi; Nicholls, Bryce T; Ouyang, Yao; Page, Claire G; Qiao, Tianzhang; Raps, Felix C; Sorigue, Damien R; Sun, Shang-Zheng; Turek-Herman, Joshua; Ye, Yuxuan; Rivas-Souchet, Ariadna; Cao, Jingzhe; Hyster, Todd K

Affiliations

Aix Marseille Univ, Inst Biosci & Biotechnol, CEA, CNRS,BIAM Cadarache - Author
Cornell Univ, Dept Chem & Chem Biol - Author
Princeton Univ, Dept Chem - Author
Univ Politecn Valencia, Inst Chem Technol ITQ - Author

Abstract

Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions involve molecules operating from their ground states. Over the past 25 years, there has been an increased interest in enzymatic processes that utilize electronically excited states accessed through photoexcitation. These photobiocatalytic processes involve a diverse array of reaction mechanisms that are complementary to one another. This comprehensive review will describe the state-of-the-art strategies in photobiocatalysis for organic synthesis until December 2022. Apart from reviewing the relevant literature, a central goal of this review is to delineate the mechanistic differences between the general strategies employed in the field. We will organize this review based on the relationship between the photochemical step and the enzymatic transformations. The review will include mechanistic studies, substrate scopes, and protein optimization strategies. By clearly defining mechanisticallydistinct strategies in photobiocatalytic chemistry, we hope to illuminate future synthetic opportunities in the area.

Keywords

Asymmetric reductionBiocatalysisBiocatalytic oxidationChemistry techniques, syntheticDirected evolutionDynamic kinetic resolutionElectron-transferElectronically excited stateEnantioselective synthesisEnzymatic processEnzyme-mediatedGround stateLight-drivenMoleculesOrganic moleculesOrganic synthesisP450 bm3 enzymesPhoto-excitationsPhotobiocatalysisReaction mechanismState of the artSynthesisSynthesis (chemical)Transition-metal-complexesVisible-light

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Chemical Reviews due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 1/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

This publication has been distinguished as a “Highly Cited Paper” by the agencies WoS (ESI, Clarivate) and ESI (Clarivate), meaning that it ranks within the top 1% of the most cited articles in its thematic field during the year of its publication. In terms of the observed impact of the contribution, this work is considered one of the most influential worldwide, as it is recognized as highly cited. (source consulted: ESI Nov 14, 2024)

And this is evidenced by the extremely high normalized impacts through some of the main indicators of this type, which, although dynamic over time and dependent on the set of average global citations at the time of calculation, already indicate that they are well above the average in different agencies:

  • Normalization of citations relative to the expected citation rate (ESI) by the Clarivate agency: 9.7 (source consulted: ESI Nov 14, 2024)
  • Weighted Average of Normalized Impact by the Scopus agency: 10.93 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 46.57 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-05, the following number of citations:

  • WoS: 85
  • Scopus: 82

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 121.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 136 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 36.3.
  • The number of mentions on the social network X (formerly Twitter): 24 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France; United States of America.