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This work was supported by Spanish MINECO (BFU2015-68199-R to P.V.) and Generalitat Valenciana (Prometeo 2014/024 to P.V.).

Analysis of institutional authors

Castelblanque, LAuthorMarti, CAuthor
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LOL2 and LOL5 loci control latex production by laticifer cells in Euphorbia lathyris

Publicated to:New Phytologist. 219 (4): 1467-1479 - 2018-09-01 219(4), DOI: 10.1111/nph.15253

Authors: Castelblanque, Lourdes; Balaguer, Begona; Marti, Cristina; Orozco, Marianela; Vera, Pablo

Affiliations

Univ Politecn Valencia, CSIC, Inst Biol Mol & Celular Plantas, Ciudad Politecn Innovac, Edificio 8E,Ingeniero Fausto Elio S-N - Author

Abstract

Laticifers are specialized plant cells capable of indefinite elongation that ramify extensively and are responsible for latex biosynthesis and accumulation. However, the mechanisms underlying laticifer cell differentiation, growth and production of latex remain largely unknown. In a search for mutants showing enhanced accumulation of latex we identified two LOT OF LATEX (LOL) loci in Euphorbia lathyris. lol2 and lol5 mutants show enhanced production of latex contained within laticifer cells. The recessive lol2 mutant carries increased biosynthesis of the plant hormone jasmonoyl-isoleucine (JA-Ile) and therefore establishes a genetic link between jasmonic acid (JA) signaling and latex production in laticifers. Instead, heightened production of latex in lol5 plants obeys to enhanced proliferation of laticifer cells. Phylogenetic analysis of laticifer-expressed genes in E.lathyris and in two other latex-bearing species, Euphorbia corallioides and Euphorbia palustris, allowed the identification of canonical JA responsive elements present in the gene promoter regions of laticifer marker genes. Moreover, we identified that the hormone JA functions not as a morphogen for laticifer differentiation but as a trigger for the fill out of laticifers with latex and the associated triterpenoids. The identification of LOL loci represents a further step towards the understanding of mechanisms controlling latex production in laticifer cells.

Keywords
Cell componentCentella-asiaticaCounterployCyclopentane derivativeCyclopentanesDefenseDicotyledonDrug effectEuphorbiaEuphorbia lathyrisGeneGene expressionGene expression regulationGene expression regulation, plantGene locusGene-expressionGenes, plantGenetic lociGeneticsGrowthHormoneIdentificationInductionJasmonic acidLatexLaticifer cellsLol mutantsMediated transformationMetabolismMethyl jasmonateMutationOxylipinOxylipinsPhylogenyPlant genePlant productPlant proteinPlant proteinsPromoterPromoter regionPromoter regions, geneticSeedlingSeedlingsTerpeneTriterpeneTriterpenesTriterpenoids

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal New Phytologist due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 8/228, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.89, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-14, the following number of citations:

  • WoS: 14
  • Scopus: 15
  • Europe PMC: 9
  • OpenCitations: 15
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-14:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 20.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 20 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.6.
  • The number of mentions on the social network X (formerly Twitter): 6 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Castelblanque Soriano, Mª Lourdes) and Last Author (Vera, P).

the author responsible for correspondence tasks has been Vera, P.