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Grant support

The authors are grateful to the Spanish Ministry of Science and Technology the financial support to this research under contract reference AGL2009-13511, and to the company Advanced Wave Sensors S.L. (www.awsensors.com) for the help provided in the development of some parts of this work.

Analysis of institutional authors

Garcia, Jose VAuthorJimenez, YolandaAuthorArnau, AntonioCorresponding Author

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October 9, 2024
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Article

Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

Publicated to:Sensors. 11 (5): 4702-4720 - 2011-05-01 11(5), DOI: 10.3390/s110504702

Authors: Montagut, Yeison; Garcia, Jose V; Jimenez, Yolanda; March, Carmen; Montoya, Angel; Arnau, Antonio

Affiliations

Univ Politecn Valencia, Dept Elect Engn, Phenomena Wave Grp, Valencia, Spain - Author
Univ Politecn Valencia, Interuniv Res Inst Bioengn & Human Ctr Technol, Valencia, Spain - Author

Abstract

Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: Delta phi/Delta m approximate to -1/m(L), where m(L) is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model.

Keywords

Acoustic biosensorsAcousticsArticleBiosensing techniquesDissipation-factorGenetic proceduresHigh fundamental frequency qcHigh fundamental frequency qcmHigh resolutionImmunosensoInstrumentationMethodologyMicrobalanceModeOscillatorPhase characterizationQcm sensorsQuartz crystal microbalanceQuartz crystal microbalance techniquesQuartz-crystal-microbalanceReadout electronicsResonant-frequencySensitivityWave biosensors

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Sensors due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2011, it was in position 14/58, thus managing to position itself as a Q1 (Primer Cuartil), in the category Instruments & Instrumentation.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 7.25, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-26, the following number of citations:

  • WoS: 26
  • Scopus: 32
  • Europe PMC: 9

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-26:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 68 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/10251/28829

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Montagut, Yeison) and Last Author (Arnau Vives, Antonio).

    the author responsible for correspondence tasks has been Arnau Vives, Antonio.